Poziv na predavanje prof. Heidi Qunhui Xie pod naslovom “Stories starting from AhR activation triggered by dioxin”

Objavljeno 27.11.2023.

Hrvatsko društvo za biokemiju i molekularnu biologiju i Institut Ruđer Bošković organiziraju zajednički znanstveni kolokvij na kojem će prof. Heidi Qunhui Xie (China Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Peking) održat predavanje pod naslovom ‘’Stories starting from AhR activation triggered by dioxin’’. 

Predavanje će se održati u u srijedu 6. prosinca 2023. u 14.00 sati u dvorani 3. krila (Institut Ruđer Bošković, Bijenička cesta 54).

Sažetak predavanja :

Acetylcholinesterase (AChE, EC3.1.1.7) plays important roles in the cholinergic neurotransmission, which has been widely recognized as a biomarker for monitoring pollutions of organophosphate and carbamate pesticides. Emerging evidence suggests a broad spectrum of environmental toxic substances is able to decrease AChE activity in various species. Dioxins are amongst these emerging environmental AChE disruptors, which are persistent organic pollutants with multiple toxic effects on the nervous system. By using enzyme-based and cell-based methods, we have demonstrated that dioxin decreased AChE activity by suppressing the gene expression via aryl hydrocarbon receptor (AhR) in human derived neuroblastoma cells. Both transcriptional and posttranscriptional regulations were involved in the AhR-mediated mechanisms. On the other hand, AChE activity was also decreased by dioxin treatment during myogenic differentiation of mouse C2C12 cells. The gene expression and the enzymatic activity were both significantly suppressed, however, via non-AhR-dependent mechanisms. The dioxin-induced inhibition of AChE expression has different mechanisms of action among different species. This difference may be due to differences in the position and number of consensus sequences of dioxin response elements on the promoters of human and mouse ACHE genes.